Gamma-hydroxybutyric acid (GHB) Critical Review Report Expert Committee on Drug Dependence Thirty-fifth Meeting
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منابع مشابه
Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter gamma-aminobutyric acid. Clinical trials have demonstrated that 50-100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol. These studies have also shown that GHB craving e...
متن کاملGamma-hydroxybutyric acid: patterns of use, effects and withdrawal.
Gamma-hydroxybutyric acid (GHB) is gaining popularity as a drug of abuse. Reports of toxicity and lethality associated with GHB use have increased. This survey study was designed to identify patterns of GHB use, its effects, and withdrawal syndrome. A survey inquiring about the effects of GHB was administered to 42 users. The results showed that GHB was used to increased feelings of euphoria, r...
متن کاملManagement of Gamma-Butyrolactone Dependence with Assisted Self-Administration of GBL
Gamma-hydroxybutyric acid (GHB) and its liquid precursor gamma-butyrolactone (GBL) have become increasingly popular beyond the clubbing culture resulting in daily consumption and dependence in the broader population. This case report illustrates the challenges of managing GHB-withdrawal and a possibly superior future approach of its management by titration and tapering of the addictive agent.
متن کاملGamma-hydroxybutyric acid (GHB) withdrawal: a case report.
GHB is an increasingly popular drug of abuse that can be associated in select cases with growing dependence and a severe withdrawal syndrome. While benzodiazepines are recommended for treatment of the withdrawal syndrome, some cases have been described as benzodiazepine-resistant. The authors describe treatment of such a case, which was unsuccessfully treated initially with benzodiazepines, the...
متن کاملClinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: a review.
AIM To examine the clinical course of gamma-hydroxybutyrate (GHB) withdrawal and generate management guidelines. DESIGN Review and analysis of all published reports of GHB or GHB precursor withdrawal identified from electronic searches. FINDINGS In total, 38 cases of GHB (n = 28) or GHB precursor (n = 10) withdrawal were identified, 36 of which were from the US. A rapidly deteriorating cour...
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تاریخ انتشار 2012